A Summer Skin Master Class: Did You Know Sun Damage Takes Years to Appear?

While it’s commonly understood that UV rays have complex and mixed effects on human health, it may surprise you to learn that it typically takes 30 years for sun damage to appear.

How are your summer vacation plans shaping up? Are you headed down the shore or to the mountains, booking a music festival, or will a picnic in your favorite park on sunny weekends fill the dog days this year?

Whichever way you choose to spend them, summer days are spent outside, and with temperatures set to soar, stocking up on hats and sunscreen is fast becoming only half the story in the fight against aging and overexposure to UV rays. There is new science dawning on invigorating DNA damage, so for this summer skin master class, we need to dive deeper … and go cellular.

Do you take good care of your skin? According to the U.S. Census data and Simmons National Consumer Survey, it’s likely that you do. Some 1.35 million Americans spend a staggering $500 or more on skin care products over any single, three-month period, and don’t forget about the millions more who pay in to the more than $500 billion skin care industry every day. Americans are spending a fortune to keep their skin looking healthy and youthful. But as it ages, the largest organ in the human body needs something more than a lotion … something that goes beyond “skin deep.”

A recent Harvard University study identified the loss of the vital coenzyme NAD (nicotinamide adenine dinucleotide) from human cells as the body ages. This is inevitable, but as a fundamental coenzyme essential to DNA repair, that’s bad news for our cells, whose main purpose it is to repair themselves. The good news is that replenishing NAD stores through the precursor enzyme NMN (nicotinamide mononucleotide) is as easy as adding NMN to your daily supplement regime with top nutraceuticals such as Herbalmax’s Reinvigorator Enhanced NMN Formula.

A recent Harvard University study identified the loss of the vital coenzyme NAD (nicotinamide adenine dinucleotide) from human cells as the body ages. The good news is that replenishing NAD stores through the precursor enzyme NMN (Nicotinamide Mononucleotide) is as easy as adding NMN to your daily supplement regime with top nutraceuticals such as Herbalmax’s Reinvigorator Enhanced NMN Formula.

What Does Sun Damage Look Like at the Cellular Level?

It may surprise you to learn that it typically takes 30 years for sun damage to appear. Remember in your 20s, when you played beach volleyball all day without sunscreen, then paid for it with sun blisters on your shoulders for a whole week? Sun damage from that weekend and others begins showing up in the form of sunspots and wrinkles during your 50s.

The Washington Post reported recently on a Yale University study in 2015 where it explained how UV sunburn leads to long-term damage and skin cancer, which occurs long after sun exposure ends.

When UV light is shined on a cell, it produces two enzymes. When combined, these enzymes create a powerful oxide — and a lot of energy. In humans, the reaction breaks apart the melanin, which is the main protector enzyme in our skin, and forms a high energy molecule. In fireflies, the result is a chemical glow. But for us, if there’s DNA nearby, that energy can go right into the DNA and do the damage usually done by photons of light.

UV rays have complex and mixed effects on human health. Nonetheless, excessive exposure to UV carries profound health risks, including atrophy, pigmentary changes, wrinkling and malignancy.

How Do I Stop Sun Damage Before It Takes Hold?

There are a few preventative measures that can be taken to avoid UV sun damage and the long-term risks of cancer associated with aging, but short of staying out of the sun entirely — which is impractical because removing sunshine completely presents its own health problems — exposure can and sometimes does sneak up on us.

Supplementing vitamin A or Retinol is vital if you overlook your sun protection this summer, and works by supporting cell turnover and collagen production, two key phenomena to natural skin reparation.

Higher-grade sunscreens, hats, sunglasses and loose clothing are everyday practical steps you can take to avoid UV rays in the first place, but what about DNA repair after the fact, after the sun’s damage is done?

Short of staying out of the sun entirely — which is impractical because removing sunshine completely presents its own health problems — exposure can and sometimes does sneak up on us.

NAD, NMN and DNA Repair

Let’s expand on the importance of NAD. NAD exists in all cells, not just human cells, but plants and all living things. NAD’s main task is assisting the cell’s survival in handling the daily onslaught of environmental changes and stressors. Things such as DNA repair and immune and inflammatory responses, which are the gatekeepers that stand in the way of us and disease, exist because of the presence of NAD. Depleting NAD stores during aging leaves people vulnerable as those essential functions break down, so replenishing NAD is fast becoming fundamental to living well, longer.

Mohamed Shaharuzzaman, Ph.D., senior research scientist at biotech firm Herbalmax, described the process of reviving NAD stores with NMN, and why products such as Herbalmax’s Reinvigorator Enhanced NMN Formula are so beneficial to skin care: “Unfortunately, NAD diminishes over time from our cells as we age, so most of us reach our 50th birthday with around half our original supplies,” he said. “Imagine an hourglass, and the sand slowly pouring from the upper chamber every day of our lives.”

NMN, the active precursor coenzyme to NAD and supplemental form, is present in products such as Reinvigorator, and is what modern biotech is all about, Shaharuzzaman said. “Pioneering discoveries like NMN catapult the fusion of current health and wellness trends with fact-based science into the mainstream beauty industry and puts the consumer firmly in the driver’s seat of his or her well-being.”

Good Health Is Cellular

Hindsight is 20/20, and although we can prevent sun damage today, when we head out into the sunshine, we cannot protect ourselves from the sunburn that already happened. The best way to take care of your skin now is by paying equal attention to the skin you can see and the cells you cannot.

Beauty may only be skin deep, but good health is truly cellular.

Running, Aging, and Living in Space

Amazon.com and Blue Horizon aerospace company billionaire Jeff Bezos believes that in the future, 90% of humans will live in colonies of giant O’Neill-style space stations. That refers to Princeton physics professor Gerard O’Neil, who in the 1970’s posited the idea of the human race living in mile-long, rotating cylindrical space colonies. Is such a thing possible? Possibly.

An article published by New Atlas reported on the Gateway Foundation wanting to build a “Rotating Space Station: a hub-and-spokes design” that, if rotating fast enough, would generate enough artificial gravity to allow a person to walk around in 2G and become “a superman rippling with muscle.”

Gateway’s promotional video reports physical results experienced by astronaut Scott Kelly once he returned to Earth after 342 days spent on the International Space Station. With Scott’s twin Mark also an astronaut, the NASA Twins Study was launched. As Scott was examined in space, Mark was monitored on Earth to track any differences between them. Scott Kelly grew two inches taller over the course of the year due to the reduced gravity environment of the ISS. There was a decline in Scott’s bone formation during his mission, however, which could forecast trouble if people in the future come and go from Earth as predicted.

How could people living in space combat such troubles? Recent developments in anti-aging would help. Susan Bailey, a biologist at Colorado State University, found that telomeres on the ends of chromosomes in Scott Kelly’s white blood cells increased in length while on the ISS. Think of telomeres as protective caps on the ends of DNA strands. When human cells divide, they replicate their DNA so that each new cell gets all the operating instructions. The shortening of telomeres is associated with body aging, due to the loss of important coding regions of DNA, which impairs cell division and thereby, cell health. Scott Kelly’s positive results might be linked to increased exercise and reduced caloric intake during his time in space, but his telomeres began to shorten again once he was back on the planet.

Astronauts returning to Earth are prone to dizziness, have thinner and weaker muscles, and experience a decrease in bone density by as much as 12 percent over a year’s time, because aging and body functions are directly related to Earth’s gravity. According to University of Waterloo researcher Richard Hughson, “Astronauts actually do get older, faster.” This is why, in space, NASA astronauts exercise for two-and a-half hours a day, six days a week, and talk to psychologists every two weeks.

How does the prospect of living on a space colony sound now?

You probably won’t make it to a space station or colony any time soon, but getting regular exercise has been proven to slow down physical decline. This is particularly true for seniors, who should consider supplements that build up levels of the molecule NAD+ (nicotinamide adenine) in cells. Why? Because a person’s NAD+ levels heavily decrease with age. By age 50, a typical person has only half the NAD+ they had at 20. By 80, NAD+ levels are almost gone, more so with men than women.

NAD+ fights DNA damage, inflammation, and boosts mitochondria, the “energy power plants” in cells. Studies have shown that supplements like Herbalmax Reinvigorator that boost the production of NAD+ provide benefits associated with exercise, may slow aging, and contribute to longer telomeres in cells.

The telomerase enzyme in our cells adds the short, repetitive telomere caps to DNA strands. If telomerase is inactivated, it accelerates aging independently of telomere length. A study published in the European Heart Journal examined the effects of endurance training, interval training (IT), and resistance training (RT) on telomerase activity and telomere length (TL) and found that endurance training and IT, but not RT, increased telomerase activity and TL, which are important for healthy aging. In space or on Earth. ET (no excuses for the pun) and IT can contribute to longer life.

If you’re not running but want to age more slowly, or desire to simply acquire the energy to become a runner, you might look into supplements that promote the production of NAD+, like Herbalmax Reinvigorator.

Another study at the Department of Internal Medicine, University of Pisa, Italy evaluated long-term physical activity, plasma antioxidant status, and conduit artery endothelial function in young and older healthy men. Results suggested regular physical activity is associated with preserved antioxidant defenses and endothelial function in older individuals.

Endothelials are cells that line the interior surface of blood vessels and lymphatic vessels. Given the 60,000 miles of blood vessels that must function well to deliver oxygen to your muscles and organs, you should know that the blood vessels of older athletes function as well as those of people half their age.

Running causes more mitochondria to sprout inside your cells. So, what if you want to start running but just don’t have the energy? In 2017, a research team at the University of Exeter discovered that applied compounds called resveratrol analogues caused inactive senescent cells (cells that don’t grow or function as they should) to divide, resulting in longer telomeres within hours of treatment.

You’ve probably seen or heard of resveratrol supplements. NMN expert David Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical, takes 750 mg of NMN and 1,000 mg of resveratrol daily. In addition to offering an amount of NMN higher than that taken by Sinclair, Herbalmax Reinvigorator also contains pterostilbene, a compound used for centuries in Ayurvedic medicine that is closely related structurally to resveratrol. Pterostilbene mimics the effects of calorie restriction on a molecular level and also activates sirtuins, proteins involved in regulating cellular processes including the aging and death of cells and their resistance to stress.

If you’re not running but want to age more slowly, or desire to simply acquire the energy to become a runner, you might look into supplements that promote the production of NAD+. Perhaps you’re past astronaut age, and may never see the inside of a rotating space colony, but you could end up feeling much better, having a longer life, and feel a rocket boost of energy, too.

Are We Older Than We Think?

What is our REAL age? A study of how our perceived age can be very different than how old we are at the cellular level.

How old are you? Frankly, it’s a question I rarely ask myself or think about anymore. When I was younger, it seemed I thought about my age all the time. The youngest of five, I just wanted to be older and thought about it constantly because ‘older’ to me meant the freedom to live how I wanted. Not that I had a particularly suppressed childhood, I didn’t, it was quite the opposite, in fact. No, I just wanted to grow up as quick as I could and do what I wanted to do. And, on reflection, I did do just that.

Soon, after my twenty-first, birthdays just disappeared into the background of a busy life. My twenties were a blur of college and travel – equal amounts of both. In my thirties, I set out to make a home and since then I’ve raised kids, a husband and a dog, and payed a mortgage. Everyone’s story really, I suppose, just a different interest rate. But now as I approach mid-life, I’ve begun to take stock, mainly in my health.

Now, usually around my birthday, I’ll do a quick calculation. Birth year to the year 2000, then add the current year – math for the everyday comes in handy every now and again. At some point in the process I’ll find it incredulous there are grown humans born after the year 2000, then I’ll reluctantly rest on a number, double-check my math on a calculator, wince, then gulp down a glass of wine or similar libation to dull the pain.

Although there are other topics that press on me, money, fulfillment, general happiness, no other has the urgency of late than health and aging do. And I’ve begun to wonder, is my body as young as I feel?

To answer that question I began to dig, deep… cellular.

If our cells are old, are we?

When one is curious about a subject in 2019, one GOOGLE’S it. There amongst the din of wrinkle creams and erectile disfunction medication, I stumbled on an extraordinary word, sirtuins.

Elysium Health successfully simplifies the complicated interaction of sirtuins in the cells as a ‘family of proteins that play a role in aging by regulating cellular health.’ Stay with me, I promise I’m not just nerding-out here. ‘They are responsible for critical biological functions like DNA expression and aspects of aging. However, sirtuins can only function in the presence of NAD+, nicotinamide adenine dinucleotide, a coenzyme found in all living cells.’ Not just humans either, every living thing.

Aging, Bingo! Okay, I was getting warmer. My curiosity peaked, I now had to know what NAD+ was. Hunting through a few books, a pile of scientific periodicals and a PubMed review or two, I was astonished to learn NAD+ not only exists in every one of our billions of cells, it’s the literal driver behind, well, life itself. In fact, without it, all living things would cease to exist. Really? Yes, I discovered. There is a current flurry of scientific study around NAD+, how it relates to overall health and age-related disease, and how scientists at Harvard University have recently yielded something remarkable.

A study there found we begin life with a full supply of NAD+. As we age, this coenzyme, literally drains from our cells, so when most of us reach our fiftieth birthday, we are working on about half our original stores. I was on to something here. Visuals help, so I think of an hourglass, and the sand slowly pouring from the upper chamber. However, in my scenario, the hourglass has no bottom and the sand blows into infinity. The resulting effect? Cells age with the loss of NAD+, and the bad news is we age too, right along with them.

What’s the big deal with NAD?

My very question, and the answer was jaw-dropping. NAD+’s main function is to facilitate redox interactions (or carry electrons from one response to another). But that’s not near the end of the story. NAD+ is critical in assisting the cell’s survival in handling the onslaught of environmental changes, that happen to us every second of every day. Things like nutrient sensing and metabolism, mitochondrial function, circadian rhythms which affect sleep patterns, immune and inflammatory responses, which are the gate keepers that stand in the way of us and disease, DNA repair, cell division and on and on.

NAD+, I found, is without a doubt a big deal, but losing so much of it by mid-life seemed to me like terrible news. Indeed, further research indicates our NAD+ levels drop to nil as we edge into old age – bad news, indeed!

I was becoming clinically depressed but lucky for me I kept reading. That same Harvard study went on to investigate how to replenish NAD+ levels and described how they had tremendous success with a bunch of old mice. It found the NAD+ precursor NMN (nicotinamide mononucleotide), given to a group of mice – the human equivalent to 90 years – over a period of time of four weeks, on average were able to run twice as long as the mice who did not receive the NMN. Since the study, the afore mentioned ‘flurry of scientific activity’ is now extending into the positive effects of NMN supplementation and the replenishment of NAD+ at a cellular level.

 Is NMN good news for aging?

The good news is, people supplementing NMN on a regular basis after their mid-forties and older have reported very positive improvements in their energy and brain function and those that pair NMN with a healthy lifestyle including strength resistance exercises have indicated a quicker response time to muscle building. This fact was of particular interest to me as I’ve noticed a significant loss in my muscle density just in the past few years.

NAD+ does occur naturally in foods like certain oily fish, mushrooms, other veg and some nuts, but it is only present in trace amount so I wondered about the NMN supplements available. A simple search turned up a number of products. Wading through many of the options and looking closer at their labels, I soon discovered the best were pure NMN of concentrations of 98 percent or higher, and do not contain artificial preservatives, sugar, starch or other fillers. Let’s just say, there are a lot of cowboys out there.

The best, like Herbalmax’s Reinvigorator formula, are science-based products which manufactures their NMN at 99 percent purity. The purer the product, I understand, the better the replenishment on our NAD stores, and in turn will have a bigger and more positive effect on our aging bodies. Another product by Mirai Labs clocks up 98 percent purity but costs significantly more.

Age is but a number

As I head into the second-half of my life I know, as I did in my younger years, I’ll spend a bit more time thinking about my age, it’s inevitable I suppose, although now it’s for entirely different reasons. Mortality is not the issue for me although it is an issue, living well with the time I have left, however long that may be, is becoming a priority.

Age is a state of mind to be sure, however, age is also a sum – whether we like it or not. We have a choice to make. We can be like the ostrich and put our heads in the sand. Of course, a choice like that always has its consequences. No, I think I’ll face aging head-on. Especially when I look at my daughter and think, I’d like to meet her kids one day and I’m fairly certain she’d like that too.

It is true, life is short and a bus could hit me tomorrow but what if it doesn’t? What if I live to one hundred and eleven (writing it out has a bigger impact) like my grandmother did, what then? How healthy do I want to be if that happens and do the choices I make now have a cost? The answer is, a very obvious, of course it does.

In the end, I’d prefer to live healthier… and longer if possible, but certainly healthier and hopefully stick around for my family. Given the choice, wouldn’t everyone?

Do Happy People Live Longer?

The United Nations’ World Happiness Report, in conjunction with the International Day of Happiness, which fell on March 20, has some bad news for the citizens of the US. For the third year running, Americans are less happy than they were in 2015. In fact, as a country, we have dropped in the ranking every year since the first report was published, and sit, rather uncomfortably now at 19, well behind Costa Rica, Switzerland and Ireland.

There is a quote currently trending rather appropriately, probably as a result of the bottom dropping out of our collective happiness, which goes something like, Happiness is the new rich and health is the new wealth. So then, the 50 million-dollar question is, are you happy? Am I? Are we as a community, culture or world, happy people, and by the way, what makes us happy? These are big questions, maybe some of the biggest. And if polls and reports are anything to go by, the answer from a staggering 70 percent of us is a disappointing, no, not really.

Although most of us strive for happiness, meaning as a race, humans do not naturally seek un-happiness, reports show, here in America, people are struggling more than ever before.

So, what is happiness and maybe more importantly, what’s been making us so unhappy?

External vs. Internal Happiness

For the lucky few on this planet who are not faced with constant peril, like living in a war zone or grappling with a terminal illness, external happiness is generally tidal, ebbing and flowing throughout our lives, both in and out of our control.

However, environmental factors, or external happiness, are only half the story. A new paradigm in aging research designates approximately fifty percent of our tendency for happiness as genetic, meaning some of us are just born with ‘happier genes’. So lately, the anti-aging scientific community has been spending a lot of energy on a little protein called situins (SIRT1), which many describe as holding the key to ‘genetic happiness’. A further breakthrough study at Harvard University has identified that the key coenzyme, NAD+ (Nicotinamide Adenine Dinucleotide), which works hand-in-hand with SIRT1, actually decreases dramatically as we age. In other words, without proper stores of NAD+, SIRT1 becomes less effective at supporting the myriad of vital functions in the body, not the least of which is cognitive health. The good news is, even if heredity has dealt us a poor hand, investigations now point directly to the success of reinvigorating these shortfalls at the cellular level, especially as we age

Let’s break down happiness

As intangible as the idea of happiness might seem, when it takes the form of a hard-scientific model, it is surprisingly quantifiable. In her widely read book, The How of Happiness, Sonja Lyubomirsky, Professor of Psychology at the University of Riverside, CA, who studies happiness in the US and elsewhere, created a simple pie chart to break down happiness based on her investigations. According to the research, around half of our happiness is innate or genetic. The remaining fifty percent is then divided loosely into two slices. The smaller portion, approximately 10 percent, cites circumstances out of our control, like war or famine, as obstacles or facilitators to our happiness while socio-economic standing, poverty, illness, geography may all contribute.

The last piece of this happy pie encompasses the thousands of deliberate external choices we make for ourselves. Things like the partner we choose, our career, the lifestyle we live and the moral or maybe more impactful, the immoral decisions we make throughout our lives, all play a significant role in our overall happiness. Ultimately, it’s about the choices we make for ourselves and the consequences, good or bad, of these choices.

Can we define happiness?

Knowing all this, how can we possibly define happiness? Easily, as it turns out. Studies start by separating personal or environmental happiness into two distinct categories. The first focuses on how we characterize our individual happiness through positive emotion; joy, contentment, affection, love, etc. Happier people tend to spend more time ‘living’ inside these emotions.

Professor Lyubomirsky admits not even the happiest among us is capable of staying in these feelings all the time, and that happy people will experience sadness too, but asserts happier people measurably spend more time in a positive place, emotionally and bounce back from bouts of unhappiness with more resilience.

The second component is personal fulfillment. Happier people are more content with their accomplishments and are acutely aware of how they are progressing towards their life goals. 

But, no matter how we build intentional happiness around ourselves, if we are straddled with a genetic deficiency or a decreased capacity for happiness as we age, is the deck, in the end, stacked against us?

Do you have happy cells?

So, how does our genetic tendency for unhappiness affect us and what does it look like at the cellular level?

Cellular health, which relies on the presence of SIRT1 and NAD+ in the cell, is proving to be intimately linked to happiness and ultimately to our physical and mental health. Authors Abel and Chatterjee, researchers at the Department of Biology, in the University of Pennsylvania, published findings on the importance of sirtuins in ‘genetic happiness’, in Biological Psychiatry, the Journal of Psychiatric Neuroscience and Therapeutics, entitled, To Stay Happy, Keep Your SIRT1 Active.

SIRT1 regulates cell processes, including the aging and death of cells and their resistance to stress. These proteins are also found to reduce depression in chronically stressed animals. But SIRT1 is only half the story. The measurable loss of NAD+ identified by Harvard scientists as we age is so significant that by the time we reach our fiftieth year, we are roughly working on half our original stores. To add insult to injury, NAD+ continues to drain to nil in our 70’s and 80’s. Science is now looking for ways to keep these critical levels up, by using a precursor coenzyme to NAD+ called NMN (Nicotinamide Mononucleotide).

But how do we restock NAD in our cells? Again, thanks to innovative bio tech companies like Herbalmax, in Southern California, the answer is not as difficult as it seems.


Senior Research Scientist at Herbalmax, Mohamed Shaharuzzaman Ph. D, explains the process of replenishing NAD stores with Nicotinamide Mononuclotide or NMN. “NMN is an active precursor coenzyme to NAD+, and has been identified as the key coenzyme to life in all cells. The exciting research at Harvard University by David Sinclair, has catapulted NMN into the mainstream nutraceutical industry and has facilitated its everyday use as a safe and highly effective way to replenish NAD+ supplies.”

Biotech engineers at Herbalmax, leaders in science-based nutraceuticals, have developed a 99% pure NMN product called Reinvigorator. The Reinvigorator product is one in a premier line of Herbalmax’s pioneering nutraceuticals designed to help support cell function as we age. “Reinvigorator replenishes NAD stores as they begin to dramatically fall after we approach our later forties, ironically, when we need them the most,” explains Dr. Shaharuzzaman.  “Giving our cells the significant boost they need for continued muscle strength, cardiovascular health, and cognitive clarity.”

The research doesn’t end with Sinclair, not by a long shot. Since the later-part of the twentieth century, a wide range of depression-related studies have also centered on how the SIRT1 and NAD+ relationship positively affect unhappiness.

Health effects of Unhappiness

In 2009, The Atlantic reported on one of the longest-ever running examinations on the human condition. A longitudinal grant, which began in 1930, followed 268 Harvard, then undergraduates. As of 2019, the results keep coming in. The most startling findings included the aging undergraduates who showed signs of depression and cognitive decline by age 50, 70 percent had died or were chronically ill by age 65.

But which is first? Does a continued state of unhappiness enable illness to set up camp in our cells, or is cellular damage the reason we succumb to disease? By all accounts the answer is probably both happen at the same time, and the effects of happiness on wellness and disease, like anything is cyclical and spirals either up or down depending on which is dominant.

The decline of our cells into disease as we age is certainly profound and the connection between longevity and maintaining a happy outlook throughout our lives is, as science has established, inextricably linked. This new paradigm in aging and wellness will continue to unravel but one thing is certain, every day presents a new opportunity to choose to live happier than the day before.

Sleep Science

How Aging Affects Our Sleep. Hitting the snooze-button on our inner clock.

If you blame the neighbor’s dog, the early alarm, the bacon burger or the grandkids for a bad night, the truth about aging and sleep loss might surprise you.

How’s your sleep been lately? If a good night’s sleep is a thing of the past instead of something that happens routinely then chances are, you’re not as young as you used to be.  

Age and sleep are not always in sync. Even in our youth, environmental factors intrude on rest, disturbing natural circadian rhythms. Anxiety, caffeine drinks, alcohol, work schedules and jet lag all play havoc with this ancient inner clock.

As we age, we begin to look for answers, grabbing this and that to get back to sound sleeping, but what if I told you age itself could be the culprit and that changes at a cellular level might be to blame?

Our circadian rhythm, or ‘The Great Clock’ that eternally ticks in time with the cycle of all life, is a powerful force. When we fall out of rhythm with it, we pay a big price. Researchers in the study of gene expression reported that circadian rhythms govern a large array of metabolic and physiological functions and are generated by an intrinsic cellular mechanism that controls a large range of physiological and metabolic processes.

The problem is, as we age, that critical coenzyme we need identified as NAD (Nicotinamide Dinucleotide) decreases, most times by half its original stores by the time we reach our fiftieth year.


Aging is inevitable for all of us but recent advances in gene study have identified a missing piece to the aging puzzle that is set to begin a new chapter in Gerontology. Harvard University scientists has discovered that as we age, NAD drains from our cells. Most of us approaching our fiftieth year are working on about half our original stores.

Why is that important? NAD and its chemical precursor, NMN (Nicotinamide Mononucleotide), exist in every cell and is the powerful force that drives a cells capacity to repair DNA.  Although we understand most of our typical sleep problems are environmental, there are deeper forces at work with the loss of NAD. NAD is critical in the cell’s response to a myriad of crucial functions including helping the body cope with environmental change. NAD makes nutrient absorption possible and governs, you guessed it, circadian rhythms which is a vital factor to maintaining a healthy, habitual sleep cycle. 

The bad news is poor sleep patterns is not just environmental. Now there is strong evidence to suggest dropping natural NAD levels from our cells as we age can have an effect. Although NAD is contained in some foods like oily fish, mushrooms and avocados, they are trace amounts at best so refilling our depleted stores through food can be a challenge. The good news is the same Harvard Study that discovered the loss of NAD in our cells reported success with replacing NAD through supplementation of NMN products in their purest form. Higher purity NMN supplements rising to the top of the NMN product market currently are from MIRAI LAB clocking in at 98 percent and the Reinvigorator product by Herbalmax, which clocks in at an astounding 99%+ purity and was also the first to offer an enhanced NMN product with cooperating compounds.


At any age, our bodies perform miracles in self-repair with every cat nap, through every night, muscle, organs, and tissue cells regenerate. Inflammation is reduced, hormone levels balance and T-Cells (white blood cells) work to strengthen the immune system. Studies at the American Physiological Society (APS) show sleep T cell numbers remained high in subjects who were not allowed to sleep.

Further, deep sleep is the state in which our bodies do much of their work. We will spend about a fifth of our night in deep sleep when we are young. But that ratio starts to fade, along with our NAD levels, and by the time you’re over 65, both could be close to zero.

There are multiple reasons for this, established sleep patterns, anxiety, disease, illness and chemical imbalances including changes at a cellular level have an enormous impact and not the least of which is the dramatic loss of NAD levels.

Replacing lost NAD at a cellular level with NMN, the direct precursor of the critical coenzyme NAD+, plays a key role in the essential biological processes of DNA repair, metabolic maintenance, energy production and cellular aging which is essential for a healthy sleep. In addition, NAD is key for metabolic, neurological, cardiovascular, and muscle health. And it is essential to choose pure, science-based, quality NMN products like Reinvigorator.   


We must understand the distinction between the life choices we make that rob our sleep, like working the night shift or spending too much time on our iPhones, and the physiological, inevitable loss of NAD from our cells as we age. It’s also important to note both of these phenomena are happening at the same time so we are faced with a double-whammy of obstacles in our way of a good night’s sleep.

Resolving our sleep issues requires us to make a few changes and sometimes difficult choices. Altering our hard and fast patterns is essential to begin the slow turn around to healthy aging and ultimately better sleep. But now we know we must also feed our cells the NAD they need to do their jobs, which is actually pretty easy with NMN supplementation.

Until now, I think we all understood that combining regular exercise, eating well and reducing stress from our lives will help us rest better – a healthy body is a key first stage. What’s been missing in healthy aging is the critical step of introducing NMN to restore the critical coenzyme NAD+ to our cells. Reinvigorating our vital stores of NAD+ with NMN has become the new essential for the home-health cabinet.