A new study published in Nature Metabolism finally reveals the answer to how NMN enters the cell in order to become NAD+ and that it does not need to convert into NR to do so.
In the last few years, there has been considerable interest in restoring levels of the nicotinamide adenine dinucleotide (NAD+) coenzyme to combat age-related diseases. Evidence suggests that NAD+ systemically declines with age in a variety of organisms, including rodents and humans, which contributes to the development of many age-related diseases and metabolic conditions.
A new analysis of data on more than 900 Baltimore adults has linked stressful life experiences among middle-aged women — but not men — to greater memory decline in later life. The researchers say their findings add to evidence that stress hormones play an uneven gender role in brain health, and align with well-documented higher rates of Alzheimer’s disease in women than men.
According to the Alzheimer’s Association, 1 in 6 women over age 60 will get Alzheimer’s disease, compared with 1 in 11 men. There currently are no proven treatments that prevent or halt progression of the disease.
“We performed a genome-wide association study of longevity-related phenotypes in individuals of European, East Asian and African American ancestry and identified the APOE and GPR78 loci to be associated with these phenotypes in our study. Moreover, our gene-level association analyses highlight a role for tissue-specific expression of genes at chromosome 5q13.3, 12q13.2, 17q21.31, and 19q13.32 in longevity. Genetic correlation analyses show that our longevity-related phenotypes are genetically correlated with several disease-related phenotypes, which in turn could help to identify phenotypes that could be used as potential biomarkers for longevity in future (genetic) studies.”
David Sinclair is among a group of researchers collaborating on a new nonprofit academy to promote aging research and drug discovery.
“We’re generally in denial that, for most of the diseases
that we get these days, the root cause is aging. I don’t know 10-year-olds that
get Alzheimer’s disease or heart disease.”- David Sinclair
The Harvard Gazette interviews David Sinclair, one of the
pioneers of longevity research and more recently known for his Harvard study into
the restoration of the Nicotinamide Adenine Dinucleotide (NAD) molecule in mouse
cells, along with 16 researchers from Harvard, MIT, and other institutions
around the U.S. and Europe, launched the nonprofit Academy for Health and Lifespan Research to promote future work, ease collaborations
between scientists, and ensure that governments and corporations are making
decisions based on the latest facts instead of rumor, speculation, or hype.
Sinclair talks frankly about his research, convincing the FDA aging is a disease, and how he plans on controlling the exploding science of longevity.
‘Tickling’ the ear with a small electrical current appears
to rebalance the autonomic nervous system for over-55s, potentially slowing
down one of the effects of ageing, according to new research at the University
The new study explores the impact the vagus nerve has on age. The therapy, called transcutaneous vagus
nerve stimulation, delivers a small, painless electrical current to the ear,
which sends signals to the body’s nervous system through the vagus nerve.
The vagus nerve runs from the brain through the face and to
the thorax, to the abdomen. It is the longest and most complex of the 12 pairs
of cranial nerves that emanate from the brain. It transmits information to or
from the surface of the brain to tissues and organs elsewhere in the body, it
is part of a circuit that links the neck, heart, lungs, and abdomen.
What causes high blood pressure and what can you do to avoid it happening to you.
The next time you are waiting in line at the Department of
Motor Vehicles, look around. The probability is good that one-in-three people,
sitting, standing, taking a number or complaining at customer service, suffer
from high blood pressure. According to the Centers for Disease Control and
Prevention (CDC), a shocking 75 million adults in the United States currently
tangle with one of the two types of the disease. The condition has held an unpleasant
place of first, on the list of top five diseases that lead to death in the U.S.
The heart has a vital but simple function. It is a muscle, that pumps blood around the
body. It has one job, but does it very well. The reason for all of that pumping
is to push blood with low oxygen levels toward the lungs, which replenishes the
blood’s oxygen supplies. When the heart constricts to create the force to push
the blood, that’s the systolic number, or the first number recorded when the
nurse or doctor takes your blood pressure. Diastolic, is the second number logged,
and the amount of pressure in the arteries when the heart relaxes before the
The heart then pumps the newly oxygen-rich blood around the
body to supply the muscles and cells. All this pumping action creates pressure
on the vessels. It is this pressure that is gauged when a sphygmomanometer, or an
inflatable cuff on the upper arm, is used as part of a regular office health
Some pressure is good, and necessary. But according to an
article on high blood pressure from Harvard University Medical School, too much
of a good thing is usually a bad thing.
Two types of
high blood pressure
Secondary Hypertension high blood pressure is a growing
problem in the U.S., and largely due to poor food choices, stress and lack of exercise.
Secondary Hypertension is when there is a known reason for the higher
levels of pressure on the blood vessels and arteries. Things that can cause Secondary
Hypertension usually include: diet, medicine, lifestyle, age, and genetics.
Conversely, Primary Hypertension or Essential Hypertension, as it’s more commonly known, make up the bulk of the cases, between 90 and 95% annually. According to Hendrick Medical Center, Primary Hypertension tends to develop gradually over many years, whereas Secondary Hypertension often comes on quickly.
impact blood pressure
If we inherit a disease, or the propensity for a disease,
our best defense is to live well, eat well, exercise and monitor the
possibility of the problem rearing its head in our life-time. Ironically, the same
formula applies for those who are born with no underlying condition, and if high
blood pressure is sustained, it largely comes down to poor choices.
Foods that are high in saturated fats, high salt and sugars,
alcohol, caffeine and a sedentary lifestyle can all translate into obesity and
the growth of plaque on the walls of the arteries. Once plaque builds up, the
arteries become tense, constricted, or rigid, and are more resistant. This
records as higher blood pressure, and makes it harder for the heart to do its
job. Think of a garden
hose, and how pliable the rubber
is during the summer months. Come winter, that same hose becomes stiff and
difficult to manipulate, and pretty much stays in the ‘O’ shape when it’s
removed from the wall mount.
That’s what happens to your arteries as plaque builds inside
them, unfortunately, and unlike the garden hose, the Spring thaw doesn’t bring
back flexibility to the arteries, and overtime, they just get more unyielding. Remembering the heart has one job to do, when
conditions are more difficult, it’s less likely it can perform its task well,
or at all.
Additionally, the relentless pounding of blood against the
walls of the arteries causes them to become harder and narrower, potentially
setting the stage for a heart attack or stroke. Without treatment, high blood
pressure, or hypertension, can lead to grave health conditions, including heart
failure, vision loss, stroke, and kidney disease.
How can I avoid
high blood pressure?
Avoiding high blood pressure means taking care of your heart
by looking after the well-being of your overall body, mind and spirit. Supporting
heart health means strengthening the muscle with exercise. Just as exercise fortifies
other muscles in your body, it also helps the heart work more efficient, making
it better able to pump blood, and when the supporting organs in the body are
functioning as they should, the heart has an easier job to do. This means that
the heart pushes out more blood with each beat, allowing it to beat slower and
keep your blood pressure under control.
It’s much easier to maintain your blood pressure when it’s
normal, than it is to fix high blood pressure after it has taken hold. So, the best time to think about it, is when
you don’t have it.
In addition to keeping fit, there are a number of common-sense rules to follow. Here are the top ten guidelines you should be mindful of to keep blood pressure at bay, and smooth your way to a happier, healthier heart.
✔ Reduce your sodium intake.
The FDA and other health authorities recommend limiting salt intake to between 1.5 and 2.3 grams of sodium per day, or 2,300 mg, which is equal to about 1 teaspoon. Yet, increasing evidence suggests that these guidelines may be too low. People with high blood pressure should not exceed 7 grams per day. Source, FDA
✔ Drink less alcohol.
Drinking too much alcohol can raise blood pressure to unhealthy levels. Having more than three drinks in one sitting temporarily increases your blood pressure, but repeated binge drinking can lead to long-term increases. Source, Mayo Clinic
✔ Eat more potassium-rich foods.
is a key mineral that the body relies on heavily to function properly. It helps
to lower blood pressure by balancing out the negative effects of salt. Your
kidneys help to control your blood pressure by controlling the amount of fluid
stored in your body. The more fluid, the higher your blood pressure. Source, Blood Pressure UK
✔ Cut back on caffeine.
can cause a short, but dramatic increase in your blood pressure, even if you
don’t have high blood pressure. Some researchers believe that caffeine blocks a
hormone that helps keep your arteries widened. Source, Mayo Clinic
✔ Learn to manage stress.
body produces a surge of hormones when you’re in a stressful situation. These
hormones temporarily increase your blood pressure by causing your heart to beat
faster and your blood vessels to narrow. Source, Mayo Clinic
✔ Eat dark chocolate or raw cocoa.
chocolate studies involving 1,106 people found that dark chocolate, the kind
that contains at least 50 to 70 percent cocoa, lowered blood pressure in all
participants, but most notably in those with hypertension. … Dark chocolate also
appears to affect cholesterol. Source, AARP
✔ Lose weight.
overweight or obese increases your risk of developing high blood pressure. In
fact, your blood pressure rises as your body weight increases. Losing even 10
pounds can lower your blood pressure—and losing weight has the biggest effect
on those who are overweight and already have hypertension. Source,
National, Heart, Lung and Blood Institute
✔ Herbal supplements.
are many different herbs that have been verified to reduce BP. One, Hawthorne
Berry, in particular has, again and again, via pharmacological and clinical
trials, been shown to effectively lower BP. The two main substances that
contribute to Hawthorn’s beneficial effects on the heart are flavonoids and
oligomeric procyanidins, which are potent antioxidant agents. Source, Role of natural herbs in
the treatment of hypertension, Nahida Tabassum and Feroz Ahmad
✔ Quit smoking.
nicotine in cigarette smoke is a big part of the problem. It raises your blood
pressure and heart rate, narrows your arteries and hardens their walls, and
makes your blood more likely to clot. It stresses your heart and sets you up
for a heart attack or stroke. Source, WebMD
techniques are increasingly popular practices that may be useful in preventing
or reducing elevated blood pressure. Transcendental meditation and
mindfulness-based stress reduction may produce clinically significant
reductions in systolic and diastolic blood pressure. Source, National, Heart, Lung and
Sources: Keiser Permanente Health Services, Mayo Clinic, National Institute of health, Harvard University Medical School
Research in mice now shows that a specific cell death
mechanism can lead to rheumatoid arthritis. Stopping this mechanism could help
prevent this condition from developing, the authors argue.
Rheumatoid arthritis (RA) is a chronic autoimmune condition
characterized mainly by pain and stiffness in the joints due to inflammation in
the joint lining.
Some of the main risk factors for RA are age (people over 60
are more at risk), sex (this condition is more common in women), and the
expression of specific genes.
According to the Arthritis Foundation, around 54
million adults in the United States have a diagnosis of arthritis. Other data
indicate that RA affects approximately 1% of the world’s population.
authors found no relationship between social interaction and cognitive decline.
However, when they delved into the beta-amyloid data, a pattern formed.
researchers found that the influence of social activity was significant in
individuals who had the highest levels of beta-amyloid in their brains. In this
group, those with the lowest levels of social interaction showed higher levels
of cognitive decline than individuals with similar levels of beta-amyloid but
greater levels of social activity.
found that individuals who had lower cognitive abilities at the start of the
study were more likely to become less socially engaged over the 3 years.
Insufficient physical activity causes around 3.2 million
deaths worldwide each year, according to the World Health Organization (WHO).
These declining levels of physical activity may be due, in
part, to an increase in sedentary behavior, heavy traffic areas, pollution, and
a lack of parks and facilities.
For adults aged 65 and above, experts define physical activity as a combination of everyday tasks, such as work duties (if applicable), transportation, chores, and exercise they do during leisure time, such as walking, swimming, and gardening.
Take this Immunity Test to check you are doing everything you can to keep your immune system strong.
Our immune system is the gate keeper,
without it, the human body could not survive on earth, with its biological
environment filled with foreign invaders, parasites, bacteria and multitudes of
viruses. On any given day, our system fights off this onslaught, sometimes simultaneously,
without our knowing.
Our immune system is a complex network of
cells, tissues and proteins that stands between the body and disease. Thankfully
our immunity is a well-tuned machine, and deals with most invaders like a
champ, but nothing is perfect, and for various reasons it can slip up, become
overwhelmed, or is busy doing other things for us, and we become sick. How
often this happens depends on how strong the immune system is, how frequently our
bodies are exposed to pathogens and what we do on a daily basis to support, or
hurt immunity through health and life choices.
We regularly talk about immunity like it’s a
singular structure, but actually it’s three. From the minute we are born, our
bodies protect us with an in-built, or an innate immunity. The minute
our bodies come into contact with an antigen, or any substance that can spark
an immune response, we begin to build our own unique adaptive immunity,
which continues to take shape through the course of our lives as we are
introduced and reintroduced to different pathogens. We can also, in essence, borrow
immunity from sources like medicine, or our mothers during breastfeeding,
but that is not a permanent protection and fades when the “immunity loan”
As immunity effects the body, the body effects immunity, and how we treat not just our physical selves, but our minds and emotional lives, leaves a powerful impression back on our immune health. How we live, what we eat, where we live, what we do for work, how we play, are all significant to the health of our immunity.
So, the question is, how are you treating
your immune system? In other words, have you accrued any annuity with your
The immune system is precisely that, a
system, not a single entity and to function well, it requires balance and
harmony. So, there are differing points of view when it comes to quantifying
the impact of good health practices have on the system of immunity, but
researchers are exploring the effects of diet, exercise, age, psychological
stress, and other factors on the immune response, both in animals and in
In the meantime, general healthy-living strategies are a good way to start giving your immune system the upper hand.
IMMUNITY HEALTH CHECK
Don’t smoke. Smoking is more than a dirty habit, it’s an assault on every cell in your body and damages the immune system, often irreparably.
Aside from the damage it does to every other
organ in the body because of the over 70 known carcinogens in a single
cigarette, there are added elements like tar, oxidizing chemicals, metals and
radio-active compounds that the body’s immune system is forced to process,
causing greater susceptibility to infections such as pneumonia and influenza
with the unwelcomed effects of longer-lasting illnesses.
Eat a diet high in fruits and vegetables. There is little debate there is a direct connection between the foods we eat and health. It is often so direct, that stomach distress can come immediately after eating a food that doesn’t agree with us.
When we eat a fatty, high sugar, processed food
diet manufactured with chemicals, colors and additives, our bodies work hard to
eliminate the toxins that are introduced. The more poisons our body have to
deal with, the less likely over-time it will effectively be able to eliminate
them, causing stress on the systems of the body, particularly the immune
Exercise regularly. Moderate exercise seems to have a beneficial effect on the immune function, which could protect against upper respiratory tract infections. Exercise has positive effects on both the humoral and the cellular immune system.
Studies among athletes have surprisingly uncovered
that after strenuous exercise, athletes pass through a period of impaired
immune resistance. Pointing to any activity that causes stress on the body,
mind or emotional state which is the root of the exhaustion. In essence, the
body does not distinguish between fatigue from exercise and exhaustion from
Maintain a healthy weight. Obesity is at epidemic proportions, and the number one factor behind many diseases today. Food manufacturers over-process with staggering measure to the point where the nutrition we take in is more often than not off-set by the way the food is made. Over the years, advertising influencers have normalized poor diet, resetting what we might consider a ‘healthy’ food. In 2016, the World Health Organization reported 1.9 billion people were overweight; that was the better part of 15 percent of the total population of 7.9 billion people at that time.
Carrying extra weight impacts every system
of the body, and as we age the effects are catastrophic. People who carry just
5% extra of their body mass are subject to disproportionate health risks such
as diabetes, cardiovascular disease, arterial disease, stroke, cancer, and
depression compromising the body’s immunity.
Drink alcohol in moderation. Alcohol impairs mucosal immunity in the gut and lowers respiratory development, and leaves the body open for progression of certain cancers.
Library of Medicine reports, clinicians observed an association between
excessive alcohol consumption and adverse immune-related health effects such as
susceptibility to pneumonia. In recent decades, this association has been
expanded to a greater likelihood of acute respiratory stress syndromes (ARDS),
sepsis, alcoholic liver disease (ALD), and certain cancers; a higher incidence
of postoperative complications; and slower and less complete recovery from
infection and physical trauma, including poor wound healing.
Get adequate sleep. Although our immune system works round the clock, it’s when we sleep that our immunity kicks into full gear. When our body rests, our immune system releases proteins called cytokines, some of which help promote sleep. Cytokines participate in many physiological processes including the regulation of immune and inflammatory responses. In turn, infection-fighting antibodies and cells are reduced during periods when you don’t get enough sleep.
Further, researchers in the study of gene
expression reported that circadian rhythms govern a large array of metabolic
and physiological functions and are generated by an intrinsic cellular
mechanism that in-turn controls a large range of physiological and metabolic
processes. So, in essence, when we lose sync with our sleep clock, a whole
range of health issues can crop up, leaving our conceded immune system to clean
up the pieces.
Avoid infection. Not as simple as it sounds as viruses or bacteria are all around us, but there are plenty of measures we can take to reduce our risks.
Get vaccinated, and make sure your kids are too.
Wash your hands frequently, especially after coughing.
Stay home if you are sick (so you do not spread the illness to other
Use a tissue, or cough and sneeze into your arm, not your hand.
Wash your hands after coughing, sneezing or using tissues.
Clean children’s toys regularly, especially if they are sharing with
Do not touch your eyes, nose or mouth with unclean hands.
Do not share cups, glasses, dishes or cutlery.
Supplement immune boosters. Support healthy immune systems with quality and 100% natural, bioactive benefits like the Immune Booster Formula by Herbalmax.
Designed to naturally and powerfully lift
the immune system, Immune Booster controls t-helper cells 1 and 2, essentially
regulating the body’s immune responses. Regular intake of Immune Booster or a
very good immune support supplement sustains the day to day silent battles our
Consider taking a best in class proprietary
blend like Immune Booster as a backup ideal for travelers and people who
frequent crowded places.
Powerful ingredients like the Astragalus and Acai Berry plants, both an essential part of the proprietary blend of the Herbalmax Immune Booster, have strong antiviral and anti-inflammatory properties as well as being highly effective free-radical scavengers, and works harmoniously with the natural biochemistry of the body to support a healthy immune system.