Owning a Dog May Add Years to Your Life, Study Shows

In a 2019 study entitled Dog Ownership and Survival, A Systematic Review and Meta-Analysis, dog ownership has been linked with decreased cardiovascular risk. Recent reports have suggested an association of dog companionship with lower blood pressure levels, improved lipid profile, and diminished sympathetic responses to stress. However, it is unclear if dog ownership is associated with improved survival as previous studies have yielded inconsistent results. Thus, we performed a systematic review and meta-analysis to evaluate the association of dog ownership with all-cause mortality, with and without prior cardiovascular disease, and cardiovascular mortality.

Scientists Have Found Longevity Biomarkers

A group of scientists from Skoltech, Moscow State University and Harvard University decided to fill this gap and identify crucial molecular processes associated with longevity. To do so, they looked at the effects of various lifespan-extending interventions on the activity of genes in a mouse, a commonly used model organism closely related to humans.

NMN Enters Cells via Newly Discovered Pathway

A new study published in Nature Metabolism finally reveals the answer to how NMN enters the cell in order to become NAD+ and that it does not need to convert into NR to do so.

In the last few years, there has been considerable interest in restoring levels of the nicotinamide adenine dinucleotide (NAD+) coenzyme to combat age-related diseases. Evidence suggests that NAD+ systemically declines with age in a variety of organisms, including rodents and humans, which contributes to the development of many age-related diseases and metabolic conditions.

‘Stressors’ in middle age linked to cognitive decline in older women Johns Hopkins Medicine

A new analysis of data on more than 900 Baltimore adults has linked stressful life experiences among middle-aged women — but not men — to greater memory decline in later life. The researchers say their findings add to evidence that stress hormones play an uneven gender role in brain health, and align with well-documented higher rates of Alzheimer’s disease in women than men. 

According to the Alzheimer’s Association, 1 in 6 women over age 60 will get Alzheimer’s disease, compared with 1 in 11 men. There currently are no proven treatments that prevent or halt progression of the disease.

A meta-analysis of genome-wide association studies identifies multiple longevity genes

“We performed a genome-wide association study of longevity-related phenotypes in individuals of European, East Asian and African American ancestry and identified the APOE and GPR78 loci to be associated with these phenotypes in our study. Moreover, our gene-level association analyses highlight a role for tissue-specific expression of genes at chromosome 5q13.3, 12q13.2, 17q21.31, and 19q13.32 in longevity. Genetic correlation analyses show that our longevity-related phenotypes are genetically correlated with several disease-related phenotypes, which in turn could help to identify phenotypes that could be used as potential biomarkers for longevity in future (genetic) studies.”

Longevity and anti-aging research: ‘Prime time for an impact on the globe’

David Sinclair is among a group of researchers collaborating on a new nonprofit academy to promote aging research and drug discovery.

“We’re generally in denial that, for most of the diseases that we get these days, the root cause is aging. I don’t know 10-year-olds that get Alzheimer’s disease or heart disease.”- David Sinclair

The Harvard Gazette interviews David Sinclair, one of the pioneers of longevity research and more recently known for his Harvard study into the restoration of the Nicotinamide Adenine Dinucleotide (NAD) molecule in mouse cells, along with 16 researchers from Harvard, MIT, and other institutions around the U.S. and Europe, launched the nonprofit Academy for Health and Lifespan Research  to promote future work, ease collaborations between scientists, and ensure that governments and corporations are making decisions based on the latest facts instead of rumor, speculation, or hype.

Sinclair talks frankly about his research, convincing the FDA aging is a disease, and how he plans on controlling the exploding science of longevity.

‘Tickle’ therapy could help slow aging, research suggests

‘Tickling’ the ear with a small electrical current appears to rebalance the autonomic nervous system for over-55s, potentially slowing down one of the effects of ageing, according to new research at the University of Leeds.

The new study explores the impact the vagus nerve has on age.  The therapy, called transcutaneous vagus nerve stimulation, delivers a small, painless electrical current to the ear, which sends signals to the body’s nervous system through the vagus nerve.

The vagus nerve runs from the brain through the face and to the thorax, to the abdomen. It is the longest and most complex of the 12 pairs of cranial nerves that emanate from the brain. It transmits information to or from the surface of the brain to tissues and organs elsewhere in the body, it is part of a circuit that links the neck, heart, lungs, and abdomen.